Fast stem cell homing method

干细胞归巢的快捷方法

Abstract

本发明提供的方法可使干细胞快速有效归巢。本发明所提供的干细胞归巢方法包括如下步骤:1)用粒径为40~60nm的免疫磁珠标记干细胞;2)将标记后的干细胞注入特定组织的循环系统内;3)将正负两个磁极指向所述特定组织相对应的体表部位,在所述循环系统的循环过程中,所述干细胞迅速准确归巢于所述特定组织内;所述正负两个磁极间的磁场强度为8400~18600Gs。本发明创新性地利用超顺磁性磁珠的磁特性,采用磁吸引技术使干细胞在特定组织归巢,可帮助干细胞在特定组织分化成有功能的成体细胞,为干细胞的临床应用开拓了新方向。
The invention provides a method which enables stem cells to be homed quickly and effectively. The stem cell homing method includes the steps that immunomagnetic beads are used for marking the stem cells, and the particle size of each immunomagnetic bead is 40-60 nanometers; the marked stem cells are injected into a circulatory system of specific tissue; and a positive magnetic pole and a negative magnetic pole point to body surface portions corresponding to the specific tissue, and in the circulation process of the circulatory system, the stem cells are homed into the specific tissue quickly and accurately, wherein the magnetic field strength between the positive magnetic pole and the negative magnetic pole is 8,400-18,600 gausses. According to the stem cell homing method, the magnetic characteristic of the superparamagnetism magnetic beads is utilized innovatively, the magnetic attraction technology is adopted to enable the stem cells to be homed into the specific tissue, the stem cells can be helped to differentiate into functional adult cells in the specific tissue, and a new direction is exploited for clinical application of the stem cells.

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Patent Citations (3)

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Cited By (2)

    Publication numberPublication dateAssigneeTitle
    CN-103245648-AAugust 14, 2013西安交通大学一种观察血管干细胞附壁的方法
    CN-103245648-BMay 27, 2015西安交通大学一种观察血管干细胞附壁的方法